Clinical pathophysiology of hibernating myocardium
نویسندگان
چکیده
منابع مشابه
REVIEW IN DEPTH Clinical pathophysiology of hibernating myocardium
Our current knowledge of the pathophysiology of chronic hibernating myocardium is mainly based on results from clinical studies, because of the absence of appropriate and validated animal models. These clinical observations have given rise to two major controversies: the role of reduced blood flow and that of histological changes in the hibernating segments. In this review, these two subjects w...
متن کاملHibernating myocardium.
Decreased myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of hibernation implies a downregulation of contractile function as an adaptation to a reduction in myocardial blood flow that serves to maintain myocardial integrity and viability during persistent ischemia. Unequivocal evidence for this concept exists in scenarios of myocardial ischemia that last...
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Classical teaching about myocardial ischemia is now being challenged by exciting new concepts that have been evolving over the past two decades. It is now recognized that prolonged myocardial ischemia does not inevitably lead to irreversible necrosis of myocardial tissue. Similarly, segment dysfunction in the ventricle does not necessarily imply that the myocardium in that area has undergone in...
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CHRONIC REVERSIBLE CONTRACTILE DYSFUNCTION is frequently identified in the evaluation of patients with coronary artery disease. There is intense clinical interest in this area because it impacts directly on clinical decision making, and it has been the subject of several recent reviews (6, 23, 25, 46, 48). Nevertheless, until recently, basic understanding of physiological mechanisms has lagged ...
متن کاملHibernating myocardium: new answers, still more questions!
In the early 1980s, Rahimtoola 1 reviewed the results of coronary bypass surgery trials and identified patients with coronary artery disease and chronic left ventricular dysfunction that improved upon revascularization. He proposed the concept of hibernating myocardium as “prolonged ischemia. . . in which myocardial metabolism and ventricular function are reduced to match the reduced blood supp...
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ژورنال
عنوان ژورنال: Coronary Artery Disease
سال: 2001
ISSN: 0954-6928
DOI: 10.1097/00019501-200108000-00007